At the age of 15, Alex Majoli joined the F45 Studio in Ravenna, working alongside Daniele Casadio. While studying at the Art Institute in Ravenna, he joined Grazia Neri Agency and traveled to Yugoslavia to document the conflict.

In 1995 Majoli went to South America for several months, photographing a variety of subjects for his ongoing personal project, Requiem in Samba. He started the project Hotel Marinum in 1998, on life in harbour cities around the world, the final goal of which was to perform a theatrical multimedia show. That same year he began making a series of short films and documentaries.

After becoming a full member of Magnum Photos in 2001, Majoli covered the fall of the Taliban regime in Afghanistan, and two years later the invasion of Iraq. He continues to document various conflicts worldwide for Newsweek, The New York Times Magazine, Granta and National Geographic.